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What does weightlessness feel like?
Short answer
Like a fall that never ends. Earth's gravity in orbit is nearly as strong as on the ground; because the station and crew fall together, weight stops being felt. The body notices this as facial swelling, a stuffy nose and often nausea; it usually passes after a few days.

Free fall, not absence of gravity
The sensation doesn't arise because gravity disappears: at the ISS's altitude it acts almost undiminished. The station, the crew and any loose pen fall together around the Earth, and orbital velocity carries them past the ground again and again without ever touching it. Anyone who knows the seconds of drop on a roller coaster knows the principle behind this sensation. Parabolic research flights offer about 20 seconds of that each time: enough for experiments, too little to get used to it.
The first week is the hardest
Without weight, blood no longer pools in the legs. Fluid shifts upward: a swollen face, thin calves, head pressure like a cold, dulled senses of smell and taste. At the same time, the balance organ reports stillness while the eyes perceive motion. Space sickness arises from that contradiction, with nausea and headaches. Up and down cease to exist; which wall counts as the floor becomes a choice.
When the body adapts
After a few days, the sensation becomes pleasant. You move with your fingertips instead of your legs and learn to dose force carefully, because any push that's too strong ends against the next wall. Tools get tied down, or they disappear. At rest, the body adopts a slightly hunched posture on its own. Muscles and bones lose load, which is why daily exercise is part of the onboard program. Upon returning, one's own arm suddenly feels surprisingly heavy.
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