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What was Boeing's first pressurized commercial airliner?
Short answer
The Boeing 307 Stratoliner, which was also the first airliner in paid commercial service with a pressurized cabin. Pressurization, combined with supercharged engines, allowed it to cruise above bad weather. Its cruising speed was 350 km/h (220 mph) at 6,100 m (20,000 ft).

The first pressurized cabin in commercial service
The Boeing 307 Stratoliner was the first airliner in commercial fare-paying service with a pressurized cabin. Pressurization, combined with supercharged engines, allowed it to cruise above bad weather. Its cruising speed was 350 km/h (220 mph) at 6,100 m (20,000 ft).
Two routes across the Atlantic
During the war, the Stratoliners that served in the US Army Air Forces under the designation C-75 flew two main routes: between Washington, D.C. and Cairo, across the South Atlantic, and between New York and Prestwick, in Scotland, across the North Atlantic. The first North Atlantic crossing by those C-75s was made in March 1942. From 22 April their crossings were already being made regularly. On 10 July 1942 the airfield on Ascension Island, in the South Atlantic, was opened.
Thousands of crossings
By the time the C-75s were withdrawn, more than 3,000 transoceanic crossings had been completed.
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