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How many passengers and what routes was the Boeing 737 originally designed for?
Short answer
For fifty to sixty passengers on routes between 50 and 1,000 miles, according to the market research behind the program. The twinjet kept the 707's fuselage width and six seats per row. Collaboration with Lufthansa stretched the original 60-seat project to 100 passengers.

The market gap that defined the project
The Boeing 737 program was based on market research that pointed to demand for an airliner seating fifty to sixty passengers. That same research narrowed down the routes the aircraft was meant to serve: journeys of between 50 and 1,000 miles. The 737-100 and 737-200 formed the family's first generation, known as the "Original" series. That first generation launched in February 1965. In the aircraft's configuration, the twinjet kept the Boeing 707's fuselage width and retained six seats per row.
Lufthansa and the stretch to a hundred seats
Lufthansa became the launch customer on February 19, 1965, with an order for 21 aircraft. With that order, the German carrier was the first non-US airline to take delivery of a new Boeing jet. The close collaboration with the launch customer ended up stretching the original project's 60-seat jet to a capacity of up to 100 passengers.
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